サイトカイン受容体

シグナル伝達
  1. チロシンキナーゼをもつもの：M-CSF, VEGFなど
  2. 狭義のサイトカイン受容体：JAK型チロシンキナーゼが会合するもの。STATがシグナルを伝える。IL, IFN, Epo, GF, レプチンなど
  3. IL-1/TNF受容体：アダプター分子TRAFなどのリン酸化を介してIKK, JNKを活性化し、NF-kBを活性化する。
  4. カスパーゼを活性化する：Fasなど
  5. セリン・トレオニンキナーゼをもつ：smad転写因子を活性化。TGFβ受容体など
  6. 三量体Gタンパクを活性化：ケモカイン受容体など
  7. Wnt/βカテニンを介する
  8. 未知のシグナルを伝える

構造上の分類

  • Ⅰ型（ヘモポエチン）受容体：EPO、TPO、G-CSF、GM-CSF、GHなど（狭義のサイトカイン受容体）
  • Ⅱ型受容体：INF受容体、IL-10, 19, 20, 22, 24, 28, 29など（狭義のサイトカイン受容体）
  • Ⅲ型（Fas/TNF）受容体：TNF, Fas, NGF, RANK, CD40, 30, 27など
  • Ⅳ型（IL-1)受容体：IL-1, IL-18など
  • ケモカイン受容体：
  • チロシンキナーゼ型受容体：
  • TGF-β受容体：

Cytokine receptor common subunit beta

GeneCSF2RB
High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.
Cytokine receptor common subunit beta
Alternative name(s):
CDw131
GM-CSF/IL-3/IL-5 receptor common beta subunit
CD_antigen: CD131
Subcellular location
Membrane; Single-pass type I membrane protein

Subunit structurei

Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits. Interacts with TMEM102; this interaction occurs preferentially in the absence of CSF2. Interacts with LYN.
Domaini
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Cytokine receptor common subunit gamma

GeneIL2RG
Common subunit for the receptors for a variety of interleukins.
Cytokine receptor common subunit gamma
Alternative name(s):
Interleukin-2 receptor subunit gamma
Short name:
IL-2 receptor subunit gamma
Short name:
IL-2R subunit gamma
Short name:
IL-2RG
gammaC
p64
CD_antigen: CD132
Involvement in diseasei
Severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell-negative (XSCID) [MIM:300400]: A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.
X-linked combined immunodeficiency (XCID) [MIM:312863]: Less severe form of X-linked immunodeficiency with a less severe degree of deficiency in cellular and humoral immunity than that seen in XSCID.2 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Subunit structurei
The gamma subunit is common to the IL2, IL4, IL7, IL15, IL21 and probably also the IL13 receptors. Interacts with SHB upon interleukin stimulation. Interacts with HTLV-1 accessory protein p12I.
Domaini
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Interferon alpha/beta receptor 1

GeneIFNAR1
Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. Can also transduce IFNB signals without the help of IFNAR2, and not activating the Jak-STAT pathway.
Post-translational modificationi
Phosphorylated on tyrosine residues by TYK2 tyrosine kinase.2 Publications
Palmitoylation at Cys-463 is required for the activation of STAT1 and STAT2.
Subunit structurei
Heterodimer with IFNAR2; in presence of interferon alpha and beta ligands, the heterodimer forms the type I interferon receptor. Interacts with STAT1 and STAT2; the interaction requires its phosphorylation at Tyr-466. Interacts with IFNAR2.
Sequence similaritiesi
Belongs to the type II cytokine receptor family.Curated
Contains 4 fibronectin type-III domains.

Interleukin-6 receptor subunit beta

GeneIL6ST
Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events.
Interleukin-6 receptor subunit beta
Short name:
IL-6 receptor subunit beta
Short name:
IL-6R subunit beta
Short name:
IL-6R-beta
Short name:
IL-6RB
Alternative name(s):
CDw130
Interleukin-6 signal transducer
Membrane glycoprotein 130
Short name:
gp130
Oncostatin-M receptor subunit alpha
CD_antigen: CD130
Post-translational modificationi
Phosphorylation of Ser-782 down-regulates cell surface expression.4 Publications
Heavily N-glycosylated.
Subunit structure
Interacts with INPP5D/SHIP1 (By similarity). Forms heterodimers composed of LIPR and IL6ST (type I OSM receptor). Also forms heterodimers composed of OSMR and IL6ST (type II OSM receptor). Homodimer. The homodimer binds two molecules of herpes virus 8/HHV-8 protein vIL-6. Component of a hexamer of two molecules each of IL6, IL6R and IL6ST. Interacts with HCK.
Domain
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.