外因性の血液凝固の開始に係わる。セリンプロテアーゼで血液中をチモーゲンとして循環している。第Xa,XIIa, IXa因子、トロンビンにより活性型のVIIa因子に変換される。組織因子とカルシウムイオンの存在下で、第VIIa因子は第X因子を限定分解で活性型Xaに変換する。組織因子とカルシウムの存在下で第IX因子の活性化も行う。
Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
Catalytic activity
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.
Post-translational modification
ビタミンK依存性のグルタミン酸のカルボキシ化によりカルシウムに結合する。
The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
O- and N-glycosylated. N-glycosylation at Asn-205 occurs cotranslationally and is mediated by STT3A-containing complexes, while glycosylation at Asn-382 is post-translational and is mediated STT3B-containing complexes before folding. O-fucosylated by POFUT1 on a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines.5 Publications
Can be either O-glucosylated or O-xylosylated at Ser-112 by POGLUT1 in vitro.
